An easy access to chromano-isoxazolines and functionalized isoxazolines
نویسندگان
چکیده
منابع مشابه
Regio- and stereoselective access to novel ring-condensed steroidal isoxazolines.
Novel 5α-androstanes containing an isoxazoline moiety condensed to ring A or D were efficiently synthetized by 1,3-dipolar cycloadditions of aryl nitrile oxides to steroidal α,β-unsaturated ketones. During the ring closures, regioisomers in which the O terminus of the nitrile oxide dipoles is attached to the β-carbon of the dipolarophile were formed in a stereoselective manner to furnish exclus...
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The five membered heterocycles isoxazolines are considered as important class of compounds in bioorganic and medicinal chemistry. They were treated as useful intermediates for transforming to large number of bioactive molecules. These classes of compounds were known to have varied biological activities. In this review, critical discussion has been made on synthetic methodologies developed, util...
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A rapid and simple procedure was devised for the synthesis of multifunctionalized cyclic β-amino esters and γ-amino alcohols via the 1,3-dipolar cycloaddition of nitrile oxides to β-aminocyclopentenecarboxylates. The opening of the isoxazoline reductive ring to the corresponding highly functionalized 2-aminocyclopentanecarboxylates occurred stereoselectively with good yields.
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Pohjakallio_176x250.indd 3 4.3.2011 10.34 Abstract_Pohjakallio_176x250.indd 3 4.3.2011 10.34Pohjakallio_176x250.indd 3 4.3.2011 10.34 2-Isoksatsoliinit ovat heterosyklisiä yhdisteitä, joita voidaan käyttää monipuolisesti synteettisinä välivaiheina erilaisten hyödyllisten rakenneyksiköiden valmistamisessa. 2-Isoksatsoliinien hyödyllisyys on pitkään perustunut niiden helppoon synteesiin erityises...
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Transition metal-mediated N-O bond cleavage reactions of heterobicycloalkene-fused 3-methyl-2-isoxazolines were investigated. Optimal cleavage conditions were found with Raney nickel/AlCl3 mediation in aqueous methanol. The reaction provided a diverse collection of novel heterobicycle-fused β-hydroxyketones with good to excellent yields (66-95%) and without the need for chromatographic purifica...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2004
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0006.304